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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
14.24
Human Site:
Y521
Identified Species:
26.11
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
Y521
P
I
D
H
V
S
F
Y
C
K
T
A
P
N
R
Chimpanzee
Pan troglodytes
XP_514624
382
43769
V280
V
G
P
L
E
S
P
V
E
D
S
L
W
P
Y
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
Y623
P
I
D
H
V
S
F
Y
C
K
T
D
P
N
T
Dog
Lupus familis
XP_542986
665
76981
Y560
P
I
D
H
V
R
F
Y
C
K
S
D
L
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
K523
V
D
Y
G
M
E
D
K
N
P
I
D
R
V
H
Rat
Rattus norvegicus
XP_230789
677
77635
K573
M
D
Y
G
M
E
D
K
N
P
I
D
N
V
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
Q504
M
D
Y
G
M
K
D
Q
N
P
I
D
N
V
L
Frog
Xenopus laevis
Q6INN8
632
72730
Y527
P
I
N
N
V
R
F
Y
C
K
A
D
P
R
K
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
Y500
P
I
N
N
V
H
F
Y
C
K
N
D
P
T
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
P483
G
L
D
D
K
T
H
P
I
E
R
Q
I
F
Y
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
P492
Y
G
M
G
K
N
N
P
V
D
K
V
N
F
Y
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
G375
S
Q
G
W
K
N
G
G
V
L
L
K
E
E
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
L371
C
S
Q
K
H
T
S
L
T
L
K
E
E
D
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
6.6
86.6
60
N.A.
0
0
N.A.
N.A.
0
53.3
53.3
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
13.3
86.6
80
N.A.
6.6
6.6
N.A.
N.A.
6.6
73.3
73.3
N.A.
N.A.
N.A.
26.6
6.6
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
39
0
0
0
0
0
0
% C
% Asp:
0
24
31
8
0
0
24
0
0
16
0
54
0
8
8
% D
% Glu:
0
0
0
0
8
16
0
0
8
8
0
8
16
8
0
% E
% Phe:
0
0
0
0
0
0
39
0
0
0
0
0
0
16
0
% F
% Gly:
8
16
8
31
0
0
8
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
24
8
8
8
0
0
0
0
0
0
0
16
% H
% Ile:
0
39
0
0
0
0
0
0
8
0
24
0
8
0
8
% I
% Lys:
0
0
0
8
24
8
0
16
0
39
16
8
0
0
24
% K
% Leu:
0
8
0
8
0
0
0
8
0
16
8
8
8
0
8
% L
% Met:
16
0
8
0
24
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
16
16
0
16
8
0
24
0
8
0
24
16
0
% N
% Pro:
39
0
8
0
0
0
8
16
0
24
0
0
31
8
0
% P
% Gln:
0
8
8
0
0
0
0
8
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
16
0
0
0
0
8
0
8
8
8
% R
% Ser:
8
8
0
0
0
24
8
0
0
0
16
0
0
8
0
% S
% Thr:
0
0
0
0
0
16
0
0
8
0
16
0
0
8
8
% T
% Val:
16
0
0
0
39
0
0
8
16
0
0
8
0
24
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
8
0
24
0
0
0
0
39
0
0
0
0
0
0
24
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _